In reply to supersteve:
Is it a Quick Release clamp or Allen key?
If QR, try lubricating the camming mechanism in the clamp. Reducing the friction in the clamp means you can exert a greater clamping force on the post. Had this happen on a couple of different qr clamps and this has worked on all of them.
Also if you are really struggling some carbon fibre assembly paste can really help as mentioned above.